The Castle Dome mining district is one of Yuma County's oldest and most productive mining locations. Its proximity to the Colorado River and relatively low rates of freight at the time permitted the mining of even low grades of ore which wouldn't have been profitable at other locations. In addition to silver and lead, the area is rich in numerous other minerals, including zinc, copper, gold, and many others. Total production from the Castle Dome mines included 10,697 short tons (9,704 t) of lead, 498,000 troy ounces (546,000 oz; 15,500,000 g) of silver, 38 short tons (34 t) of zinc, 36 short tons (33 t) of copper, 2,000 troy ounces (2,200 oz; 62,000 g) of gold, and 7,000 troy ounces (7,700 oz; 220,000 g) of placer gold production, mostly prior to 1900.

The Castle Dome mining district is a popular district for mineral collectors. The region is known for striking combinations of cerussite, fluorite, vanadinite, wulfenite, barite, and mimetite, as well as galenite and anglesite. The Hull Mine and Puzzler Mine in particular have produced atypical green vanadinite and mimetite as well as yellow-hued wulfenite.

The area was home to the town and mining camp of Castle Dome based around the Castle Dome Mine which first produced silver and later lead. The post office opened in 1875 and closed in 1876. Castle Dome ghost town is now a museum site, with twenty or so restored period buildings.

Castle Dome Landing was the port and supply point nearby on the Colorado River. The townsite is now submerged beneath the Imperial Dam reservoir.